The King will travel to Poland to mark the 80th anniversary of the liberation of the former Nazi concentration camp Auschwitz-Birkenau.
Charles will join other dignitaries and Holocaust survivors at a service held at the Auschwitz-Birkenau museum and memorial at the end of January.
He will also meet members of the local community in Krakow before the service, Buckingham Palace has said.
Away from the Holocaust anniversary, the King is set to meet Poland’s President Andrzej Duda during his fifth trip to the country.
He previously visited in 2008 with Queen Camilla, and in 2010 as part of a wider European tour which also took in Hungary and the Czech Republic.
The King will also host a reception at Buckingham Palace to mark Holocaust Memorial Day on 27 January.
The event will showcase projects aimed at educating future generations about the Holocaust and Charles will meet 94-year-old Manfred Goldberg, who survived concentration camps, including Stutthof, and a death march.
More than a million people, mostly Jews but also Poles, Soviet prisoners of war and other nationalities, were murdered by the Nazis at Auschwitz-Birkenau during the Second World War.
The camp was liberated by soldiers of the 60th Army of the First Ukrainian Front who opened the gates on 27 January 1945.
In total, around six million Jewish men, women and children were killed in the Holocaust, along with millions of non-Jews from other groups persecuted by the Nazis.